Prospective of managing impaired brain insulin signalling in late onset Alzheimers disease with excisting diabetic drugs
نویسندگان
چکیده
منابع مشابه
The Implication of the Brain Insulin Receptor in Late Onset Alzheimer’s Disease Dementia
Alzheimer's disease (AD) is progressive neurodegenerative disorder characterized by brain accumulation of the amyloid β peptide (Aβ), which form senile plaques, neurofibrillary tangles (NFT) and, eventually, neurodegeneration and cognitive impairment. Interestingly, epidemiological studies have described a relationship between type 2 diabetes mellitus (T2DM) and this pathology, being one of the...
متن کاملMechanisms of Brain Aging Regulation by Insulin: Implications for Neurodegeneration in Late-Onset Alzheimer's Disease
Insulin and IGF seem to be important players in modulating brain aging. Neurons share more similarities with islet cells than any other human cell type. Insulin and insulin receptors are diffusely found in the brain, especially so in the hippocampus. Caloric restriction decreases insulin resistance, and it is the only proven mechanism to expand lifespan. Conversely, insulin resistance increases...
متن کاملMutational Screening in Exon 6 of the PSEN2 Gene in Iranian Patients with Late-Onset Alzheimer\'s Disease
Background and Aims: One of the most important genes involved in Alzheimer's disease (AD) is the presenilin2 (PSEN2) gene, which is one of the main constituents of the gamma-secretase complex. Mutations in this gene promote the formation of amyloid plaques resulting in AD. The study aimed to evaluate the mutation variant in exon 6 of the PSEN2 gene in patients with Late-Onset AD (LOAD). Due to ...
متن کاملbone density in patients with late onset pompe disease
background pompe disease is an inherited metabolic disorder characterized by α-glycosidase deficiency, which leads to lysosomal glycogen accumulation in many different tissues. the infantile form is the most severe with a rapidly fatal outcome, while the late onset form has a greater phenotypic variability, characterized by skeletal muscle dysfunction and early respiratory involvement. bone min...
متن کاملIntroducing a Specimen of Annular Pancreas (with late-onset Symptoms)
Annular pancreas is a relatively rare congenital diseasecaused by an embryologica1and anatomical disturbance in pancreas It may have no sympforns throughout the life and so occasionally discovered during an unrelevant surgery or autopsy but in most of the cases it shows itself as a duodenal obstruction during the infancy and childhood.Very rarely symptoms of the disease my be observed in adul...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Diabetes & Metabolic Disorders
سال: 2019
ISSN: 2251-6581
DOI: 10.1007/s40200-019-00405-2